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Hyperglycemiain some cases extreme and associated with ketoacidosis or hyperosmolar coma or deathhas been reported in patients treated with atypical antipsychotics including olanzapineAssessment of the relationship between atypical antipsychotic use and glucose abnormalities is complicated by the possibility of an increased background risk of diabetes mellitus in patients with schizophrenia and the increasing incidence of diabetes mellitus in the general populationEpidemiological studies suggest an increased risk of treatment-emergent hyperglycemia-related adverse reactions in patients treated with the atypical antipsychoticsWhile relative risk estimates are inconsistentthe association between atypical antipsychotics and increases in glucose levels appears to fall on a continuum and olanzapine appears to have a greater association than some other atypical antipsychotics.

Call your doctor if your symptoms do not improveor if they get worse while using Zyprexa.

When using Zyprexa and fluoxetine in combinationalso refer to the Adverse Reactions section of the package insert for Symbyax.

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zyprexa is not approved for the treatment of patients with dementia-related psychosis.

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